Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380624 | 0.88 | PKM (0.44) | THRBLMNASMN1; SMN2MAPK1SIGMAR1 | |
| SCHEMBL28745565 | 0.86 | THRB (0.38) | THRBLMNASMN1; SMN2MAPK1MAPT | |
| SCHEMBL7389426 | 0.85 | THRB (0.45) | THRBLMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL7378952 | 0.85 | MAPT (0.44) | THRBLMNASIGMAR1MAPTMEN1 | |
| SCHEMBL7392262 | 0.84 | THRB (0.51) | THRBLMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL7380241 | 0.84 | THRB (0.46) | THRBLMNAMAPTKMT2AALDH1A1 | |
| SCHEMBL7393478 | 0.83 | TNF (0.44) | THRBSMN1; SMN2SIGMAR1MAPTMEN1 | |
| SCHEMBL7392425 | 0.82 | THRB (0.44) | THRBLMNAMAPK1SIGMAR1MAPT | |
| SCHEMBL7380486 | 0.82 | THRB (0.40) | THRBLMNASIGMAR1MAPTRAB9A | |
| SCHEMBL7389977 | 0.81 | THRB (0.46) | THRBLMNASIGMAR1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |