Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | GBA1 | P04062 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7388647 | 0.88 | MAPT (0.48) | MAPTGBA1THRBPOLBGRM5 | |
| SCHEMBL7592402 | 0.86 | MAPT (0.46) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL7392425 | 0.85 | THRB (0.44) | MAPTGBA1HTTTHRBLMNA | |
| SCHEMBL7380241 | 0.85 | THRB (0.46) | MAPTGBA1THRBPOLBGRM2 | |
| SCHEMBL7388548 | 0.85 | MAPT (0.45) | MAPTGBA1HTTTHRBPOLB | |
| SCHEMBL7381271 | 0.85 | SIGMAR1 (0.46) | MAPTHTTTHRBPOLBGRM5 | |
| SCHEMBL7387692 | 0.85 | THRB (0.42) | MAPTHTTTHRBGRM5LMNA | |
| SCHEMBL7386967 | 0.85 | MAPT (0.44) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL7379080 | 0.84 | THRB (0.45) | MAPTTHRBPOLBLMNATP53 | |
| SCHEMBL7389681 | 0.84 | THRB (0.46) | MAPTTHRBPOLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |