Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386638 | 0.89 | THRB (0.47) | THRBSIGMAR1LMNAMAPTP2RX3 | |
| SCHEMBL7390212 | 0.88 | P2RX3 (0.43) | THRBSIGMAR1LMNAMAPTLIPE | |
| SCHEMBL7388878 | 0.87 | MAPT (0.46) | THRBKMT2AMEN1SIGMAR1LMNA | |
| SCHEMBL7482907 | 0.86 | THRB (0.44) | THRBGBA1SIGMAR1TSHRHTT | |
| SCHEMBL7378952 | 0.85 | MAPT (0.44) | THRBKMT2AMEN1GBA1SIGMAR1 | |
| SCHEMBL7388548 | 0.85 | MAPT (0.45) | THRBGBA1SIGMAR1LMNATSHR | |
| SCHEMBL7380624 | 0.85 | PKM (0.44) | THRBKMT2AMEN1GBA1SIGMAR1 | |
| SCHEMBL27541037 | 0.85 | THRB (0.41) | THRBKMT2AMEN1GBA1LMNA | |
| SCHEMBL7393171 | 0.84 | THRB (0.42) | THRBSIGMAR1LMNAHTTP2RX3 | |
| SCHEMBL7388914 | 0.84 | THRB (0.46) | THRBSIGMAR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056743-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999031092-A1 | BENZAMINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |