Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | METAP1 | P53582 | 3/20 | 0.41 |
| ▸ | REN | P00797 | 11/20 | 0.36 |
| ▸ | ACP3 | P15309 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7389599 | 0.88 | PSEN1 (0.40) | REN | |
| SCHEMBL7394314 | 0.88 | PSEN1 (0.40) | REN | |
| SCHEMBL7388372 | 0.87 | METAP2 (0.41) | METAP2METAP1REN | |
| SCHEMBL7389062 | 0.81 | PSEN1 (0.42) | REN | |
| SCHEMBL7387941 | 0.81 | MMP2 (0.49) | REN | |
| SCHEMBL7394306 | 0.81 | BCHE (0.40) | REN | |
| SCHEMBL7391215 | 0.81 | BCHE (0.40) | REN | |
| SCHEMBL7383641 | 0.80 | REN (0.47) | RENCTSD | |
| SCHEMBL7394858 | 0.79 | REN (0.46) | RENCTSD | |
| SCHEMBL7392096 | 0.79 | MMP3 (0.44) | RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0589445-B1 | Renin Inhibiting N-(2-Amino-2-oxoethyl)Butanediamide Derivatives | BIO MEGA BOEHRINGER INGELHEIM (CA) | 1997-01-15 | — | — | EP | claimed |
| WO-1994007846-A1 | RENIN INHIBITING N-(2-AMINO-2-OXOETHYL)BUTANEDIAMIDE DERIVATIVES | BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) | 1994-04-14 | — | — | WO | claimed |