Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386753 | 0.85 | ALDH1A1 (0.40) | ALDH1A1HSD17B10KMT2AKDM4EHPGD | |
| SCHEMBL7391360 | 0.84 | ALDH1A1 (0.39) | ALDH1A1HSD17B10KMT2AKDM4EHPGD | |
| SCHEMBL7386602 | 0.81 | ALDH1A1 (0.37) | ALDH1A1HSD17B10KMT2AKDM4EHPGD | |
| SCHEMBL7381519 | 0.80 | LMNA (0.47) | ALDH1A1HSD17B10KMT2AKDM4EHPGD | |
| SCHEMBL3066907 | 0.78 | LMNA (0.48) | TLR4ALDH1A1MAPTHSD17B10KMT2A | |
| SCHEMBL7387145 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HSD17B10KMT2AKDM4EMEN1 | |
| SCHEMBL7388692 | 0.77 | ACE (0.39) | ALDH1A1TSHR | |
| SCHEMBL74445 | 0.76 | L3MBTL1 (0.50) | TLR4ALDH1A1MAPTHSD17B10KMT2A | |
| SCHEMBL13106060 | 0.76 | LMNA (0.49) | TLR4ALDH1A1MAPTHSD17B10KMT2A | |
| SCHEMBL15265428 | 0.76 | LMNA (0.49) | TLR4ALDH1A1MAPTHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5426103-A | Endopeptidase inhibitors; condensing macrocylic compound with a thioic acid or salt therof; possible esterification, salt formation, deslating, deprotecting, deesterifying of function-al groups | CIBA-GEIGY CORPORATION (US) | 1995-06-20 | — | — | US | disclosed |
| US-5244889-A | Treatment of cardiovascular disorders | CIBA-GEIGY CORPORATION (US) | 1993-09-14 | — | — | US | disclosed |
| EP-0544620-A1 | Macrocyclic lactams as inhibitors of atrial natriuretic factors (ANF)-degrading neutral endopeptidase (NEP) | CIBA-GEIGY AG (CH) | 1993-06-02 | — | — | EP | disclosed |