Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7391714 | 0.88 | PTPN1 (0.67) | PTPN1PTPN2PTPN6PTPN11KDM4E | |
| Bromide SCHEMBL10730898 | 0.87 | PTPN1 (0.65) | PTPN1PTPN2PTPN6PTPN11KDM4E | |
| SCHEMBL7398136 | 0.86 | POLB (0.55) | PTPN1PTPN2PTPN6PTPN11POLB | |
| SCHEMBL7366117 | 0.82 | P4HTM (0.53) | PTPN1PTPN2MAPK1PTPN6PTPN11 | |
| SCHEMBL10338395 | 0.81 | KCNH2 (0.43) | GAAMAPK1HTTPOLBSMN1; SMN2 | |
| SCHEMBL7370129 | 0.80 | PTGS1 (0.50) | PTPN1PTPN2PTPN6PTPN11SMN1; SMN2 | |
| SCHEMBL2778375 | 0.80 | XDH (0.52) | GAAMAPK1KDM4EHTTL3MBTL1 | |
| SCHEMBL7398696 | 0.80 | DYRK1B (0.47) | GAAPTPN1PTPN2PTPN6PTPN11 | |
| SCHEMBL10553848 | 0.78 | ALDH1A1 (0.52) | GAAKDM4EHTTL3MBTL1POLB | |
| SCHEMBL7303291 | 0.78 | HDAC1 (0.46) | PTPN1PTPN6PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |