Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5088831 | 0.83 | RAB9A (0.49) | — | |
| SCHEMBL7297915 | 0.81 | KDM4E (0.52) | — | |
| SCHEMBL7398136 | 0.80 | POLB (0.55) | PTPN1PTPN6PTPN11 | |
| SCHEMBL7391714 | 0.79 | PTPN1 (0.67) | PTPN1PTPN6PTPN11 | |
| Bromide SCHEMBL10730898 | 0.78 | PTPN1 (0.65) | PTPN1PTPN6PTPN11 | |
| SCHEMBL7396608 | 0.78 | GAA (0.56) | PTPN1PTPN6PTPN11 | |
| SCHEMBL7366117 | 0.76 | P4HTM (0.53) | PTPN1PTPN6PTPN11 | |
| SCHEMBL2778375 | 0.75 | XDH (0.52) | — | |
| SCHEMBL7398696 | 0.75 | DYRK1B (0.47) | PTPN1PTPN6PTPN11 | |
| SCHEMBL7278792 | 0.74 | METAP2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0146282-A2 | Pyrazinone compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-26 | — | — | EP | claimed |
| EP-0146282-A2 | Pyrazinone compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-26 | — | — | EP | disclosed |