Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9014731 | 0.88 | MAPT (0.42) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL9014658 | 0.88 | MEN1 (0.41) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL9466374 | 0.83 | HTR1A (0.51) | HTR1AALDH1A1LMNA | |
| SCHEMBL9014693 | 0.81 | SIGMAR1 (0.55) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7397186 | 0.79 | MAPK1 (0.54) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL9181634 | 0.77 | HTR1A (0.53) | HTR1AALDH1A1LMNA | |
| SCHEMBL9176498 | 0.76 | PTGDR2 (0.40) | HTR1ADRD2ALDH1A1KMT2AMEN1 | |
| SCHEMBL7403392 | 0.72 | MAPK1 (0.56) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL7805256 | 0.71 | DRD2 (0.72) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL6960133 | 0.70 | DRD2 (0.58) | HTR1AADRA2ADRD2ADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |