Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6340136 | 0.81 | ALDH1A1 (0.59) | BRD4EPHX2BRDTALDH1A1 | |
| SCHEMBL6335139 | 0.78 | ALDH1A1 (0.56) | BRD4EPHX2TSHRBRDTALDH1A1 | |
| SCHEMBL7402278 | 0.78 | DRD2 (0.50) | BRD4GAATSHRMAOAMAP2K1 | |
| SCHEMBL7399263 | 0.76 | MAOA (0.51) | BRD4GAATSHRMAOAMAP2K1 | |
| SCHEMBL7401016 | 0.75 | DRD2 (0.66) | BRD4MAOAMAP2K1 | |
| SCHEMBL17040279 | 0.73 | MAOA (0.44) | BRD4MTNR1BCHRM2CHRM1KCNA5 | |
| SCHEMBL7398714 | 0.72 | MAOA (0.48) | BRD4TSHRMAOAMAP2K1ALDH1A1 | |
| SCHEMBL17037445 | 0.72 | MAOA (0.42) | BRD4DRD3KCNA5MAOAMAP2K1 | |
| SCHEMBL7398210 | 0.71 | KDM4E (0.47) | GAATSHRCHRM2CHRM1MAOA | |
| SCHEMBL6333808 | 0.71 | BRD4 (0.54) | BRD4BRDTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5206233-A | Antidepressants, antiischemic agents | WARNER-LAMBERT COMPANY (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1993004053-A1 | SUBSTITUTED THIAZEPINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |