Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 17/20 | 0.52 |
| ▸ | MMP9 | P14780 | 15/20 | 0.52 |
| ▸ | MMP1 | P03956 | 15/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP8 | P22894 | 3/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502886 | 0.79 | ADAM17 (0.58) | MMP13ADAM17MMP9MMP1MMP2 | |
| Acetohydroxamic Acid SCHEMBL3940028 | 0.74 | ADAM17 (0.64) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL3940026 | 0.74 | MMP9 (0.62) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL3947833 | 0.71 | MMP9 (0.77) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL6628728 | 0.71 | MMP9 (0.69) | MMP13ADAM17MMP9MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL3946389 | 0.70 | MMP9 (0.68) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL3940955 | 0.70 | ADAM17 (0.64) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL6625851 | 0.69 | MMP13 (1.00) | MMP13ADAM17MMP9MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL3938354 | 0.69 | MMP13 (0.98) | MMP13ADAM17MMP9MMP1MMP2 | |
| SCHEMBL6501401 | 0.68 | MMP9 (0.65) | MMP13ADAM17MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144368-A2 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | American Cyanamid Company (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000044709-A2 | ACETYLENIC α-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |