Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.58 |
| ▸ | MMP13 | P45452 | 10/20 | 0.58 |
| ▸ | MMP9 | P14780 | 9/20 | 0.58 |
| ▸ | MMP1 | P03956 | 8/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetohydroxamic Acid SCHEMBL3940028 | 0.79 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1PSEN1 | |
| SCHEMBL7397646 | 0.79 | MMP13 (0.52) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL3940026 | 0.78 | MMP9 (0.62) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6499171 | 0.76 | MMP9 (0.81) | ADAM17MMP13MMP9MMP1CXCR3 | |
| SCHEMBL6501401 | 0.74 | MMP9 (0.65) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL3940955 | 0.74 | ADAM17 (0.64) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6625851 | 0.74 | MMP13 (1.00) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6506710 | 0.73 | MMP9 (0.76) | ADAM17MMP13MMP9MMP1CXCR3 | |
| Hydrochloric Acid SCHEMBL3938354 | 0.73 | MMP13 (0.98) | ADAM17MMP13MMP9MMP1MMP2 | |
| SCHEMBL6498854 | 0.72 | MMP9 (0.62) | ADAM17MMP13MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | WYETH HOLDINGS CORPORATION | 2005-05-26 | — | — | US | disclosed |
| EP-1144368-B1 | ACETYLENIC ALPHA-AMINO ACID-BASED SULFONAMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6225311-B1 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors | AMERICAN CYANAMID COMPANY | 2001-05-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113346-A1 | Acetylenic alpha-amino acid-based sulfonamide hydroxamic acid tace inhibitors | TNF, SI, MMP12 | ADAM17 30/4885MMP13 115/4885MMP9 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.