Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500734 | 0.82 | KMT2A (0.49) | POLBALDH1A1KMT2APAX8RORC | |
| SCHEMBL6932753 | 0.81 | KMT2A (0.48) | POLBALDH1A1KMT2APAX8 | |
| SCHEMBL2195902 | 0.80 | MMP13 (0.45) | POLBALDH1A1ARKMT2AMMP1 | |
| SCHEMBL6799380 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KMT2AMMP1MMP2MMP9 | |
| SCHEMBL6500107 | 0.78 | KDM4E (0.41) | ALDH1A1KMT2ALGMN | |
| SCHEMBL6500180 | 0.77 | MMP13 (0.46) | MMP1MMP2MMP9MMP13PTPRC | |
| SCHEMBL7135245 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KMT2A | |
| SCHEMBL18740367 | 0.73 | CTNNB1 (0.46) | POLBALDH1A1KMT2A | |
| SCHEMBL7815451 | 0.72 | HSD11B1 (0.44) | ALDH1A1MMP13 | |
| SCHEMBL8347959 | 0.72 | LMNA (0.56) | POLBALDH1A1KMT2AMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225311-B1 | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors | AMERICAN CYANAMID COMPANY | 2001-05-01 | — | — | US | disclosed |