Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380564 | 0.83 | PDE4B (0.43) | PDE4BPDE4DPGK1ALDH1A1POLB | |
| SCHEMBL12844701 | 0.79 | PGK1 (0.41) | PDE4BPDE4DPGK1GSK3BMAP4K2 | |
| SCHEMBL11640261 | 0.79 | PDE4B (0.40) | PDE4BPDE4DPGK1ALDH1A1POLB | |
| SCHEMBL11454393 | 0.76 | DYRK1A (0.39) | PDE4BPDE4DPGK1ALDH1A1POLB | |
| SCHEMBL4778825 | 0.76 | PDE4B (0.43) | PDE4BPDE4DPGK1KDM1AMAOB | |
| SCHEMBL9024006 | 0.75 | PDE4B (0.43) | PDE4BPDE4DPGK1ALDH1A1KDM4E | |
| SCHEMBL9132120 | 0.74 | SMN1; SMN2 (0.47) | PDE4BPDE4DALDH1A1POLBKDM4E | |
| Hydrochloric Acid SCHEMBL14999713 | 0.74 | PDE4B (0.42) | PDE4BPDE4DPGK1KDM1AMAOB | |
| SCHEMBL14655577 | 0.73 | PGK1 (0.40) | PDE4BPDE4DPGK1ALDH1A1POLB | |
| SCHEMBL11070566 | 0.73 | LMNA (0.47) | PDE4BPDE4DPGK1GSK3BMAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157009-A1 | DOPAMINE D1 RECEPTOR AGONIST COMPOUNDS | CeNeS Limited (GB) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000049000-A1 | DOPAMINE D1 RECEPTOR AGONIST COMPOUNDS | CENES LIMITED (GB) | 2000-08-24 | — | — | WO | disclosed |
| EP-0476156-B1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | EISAI CO LTD (JP) | 1996-08-07 | — | — | EP | disclosed |
| US-5292521-A | And an organic acid or salt | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| EP-0476156-A1 | SOLID ORAL PREPARATION CONTAINING CATECHOL COMPOUND | Eisai Co., Ltd. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-4321195-A | 6-Halo-7,8-dimethoxy-1-(methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |
| US-4197297-A | 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1980-04-08 | — | — | US | disclosed |
| US-4111957-A | DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |