Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261390 | 0.75 | NPC1 (0.46) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL8382495 | 0.74 | DAO (0.43) | HSD17B10TDP1MEN1KMT2ACYP2C9 | |
| SCHEMBL11656026 | 0.73 | NPC1 (0.47) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6516769 | 0.70 | RAB9A (0.45) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| Ethylamine SCHEMBL6158093 | 0.69 | NPC1 (0.58) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL938200 | 0.68 | RAB9A (0.47) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL10712470 | 0.68 | BACE1 (0.47) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3316024 | 0.66 | KMT2A (0.50) | HPGDMAPTSMN1; SMN2HSD17B10TDP1 | |
| SCHEMBL11254229 | 0.66 | NPC1 (0.51) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2261412 | 0.65 | ALDH1A1 (0.52) | HPGDMAPTSMN1; SMN2HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| EP-0807621-A1 | Derivatives of phenylglycine and use thereof as pharmaceuticals | LILLY INDUSTRIES LIMITED (GB) | 1997-11-19 | — | — | EP | disclosed |