Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403129 | 0.80 | GNAI3 (0.49) | GNAO1ACHEHRH3HTR7MEN1 | |
| SCHEMBL7455560 | 0.78 | HRH3 (0.57) | GNAO1ACHEHRH3CYP1A2 | |
| SCHEMBL7400559 | 0.78 | L3MBTL1 (0.47) | GNAO1ACHEHRH3HTR7HTR1A | |
| SCHEMBL3424285 | 0.77 | ACHE (0.48) | GNAO1ACHEHRH3CHRM1CHRM2 | |
| SCHEMBL7398847 | 0.77 | SIGMAR1 (0.56) | HRH3HTR7CHRM4 | |
| SCHEMBL7401339 | 0.77 | SIGMAR1 (0.56) | HRH3HTR7CHRM4 | |
| SCHEMBL7396651 | 0.77 | SIGMAR1 (0.56) | HRH3HTR7CHRM4 | |
| SCHEMBL7319420 | 0.77 | GNAO1 (0.64) | GNAO1KCNH2GNAI3GNAI1 | |
| SCHEMBL7738066 | 0.77 | GNAO1 (0.64) | GNAO1KCNH2GNAI3GNAI1 | |
| SCHEMBL3424280 | 0.76 | ACHE (0.45) | GNAO1ACHEHRH3CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995024390-A1 | NOVEL PHENYL(-ALKYL/ALKOXY)-1-AMINOALKYL-SUBSTITUTED PIPERIDINES AND PYRROLIDINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-09-14 | — | — | WO | disclosed |