Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | DCUN1D2 | Q6PH85 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | HNF4A | P41235 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397570 | 0.83 | DCUN1D1 (0.47) | DCUN1D1DCUN1D2LMNAALDH1A1ADORA2A | |
| SCHEMBL29499607 | 0.83 | DCUN1D1 (0.47) | DCUN1D1DCUN1D2LMNAALDH1A1ADORA2A | |
| SCHEMBL29034386 | 0.80 | DCUN1D1 (0.45) | DCUN1D1DCUN1D2LMNAALDH1A1ADORA2A | |
| SCHEMBL5485083 | 0.78 | NPC1 (0.44) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL6957790 | 0.75 | DCUN1D1 (0.34) | DCUN1D1DCUN1D2 | |
| SCHEMBL12615990 | 0.74 | ALDH1A1 (0.38) | DCUN1D1DCUN1D2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL4436864 | 0.74 | MKNK1 (0.47) | LMNAL3MBTL1ALDH1A1KDM4EPOLB | |
| SCHEMBL9155822 | 0.74 | ABL1 (0.47) | DCUN1D1DCUN1D2MEN1KMT2A | |
| SCHEMBL6958012 | 0.74 | TSHR (0.35) | DCUN1D1DCUN1D2 | |
| SCHEMBL6849542 | 0.73 | HNF4A (0.42) | DCUN1D1DCUN1D2HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | disclosed |
| WO-1991018888-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-12-12 | — | — | WO | disclosed |