Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440546 | 0.77 | NOTUM (0.45) | MGLLBRS3TSHRNPC1RAB9A | |
| SCHEMBL1186753 | 0.77 | BRS3 (0.38) | BRS3NPC1RAB9AMEN1LMNA | |
| SCHEMBL7463145 | 0.77 | BRS3 (0.35) | BRS3PDPK1 | |
| SCHEMBL2211763 | 0.76 | KDM4E (0.46) | BRS3TSHRNPC1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL4739527 | 0.76 | NOTUM (0.44) | MGLLBRS3TSHRNPC1RAB9A | |
| SCHEMBL12100217 | 0.73 | CYP2A6 (0.42) | CYP2A6FAAHMGLLTSHRHCAR1 | |
| SCHEMBL19106908 | 0.72 | NOTUM (0.50) | MGLLBRS3NPC1RAB9AMEN1 | |
| SCHEMBL13104792 | 0.72 | BRS3 (0.35) | BRS3TSHRPDPK1 | |
| SCHEMBL14895448 | 0.71 | ALDH1A1 (0.40) | BRS3PDPK1 | |
| SCHEMBL7321916 | 0.69 | KDM4E (0.46) | TSHRNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683689-B1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER (US) | 2017-04-12 | — | — | EP | disclosed |
| CN-103443079-B | Fluoropyridone derivatives useful as antibacterial agents | PFIZER | 2015-06-03 | — | — | CN | disclosed |
| CN-104529883-A | Fluoro-pyridinone derivatives useful as antibacterial agents | PFIZER | 2015-04-22 | — | — | CN | disclosed |
| US-8779148-B2 | Fluoro-pyridinone derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20140057919-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2014-02-27 | — | — | US | disclosed |
| EP-2683689-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8624034-B2 | Fluoro-pyridinone derivatives useful as antibacterial agents | PFIZER INC. (US) | 2014-01-07 | — | — | US | disclosed |
| CN-103443079-A | Fluoropyridone derivatives useful as antibacterial agents | PFIZER | 2013-12-11 | — | — | CN | disclosed |
| US-20120232083-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC | 2012-09-13 | — | — | US | disclosed |
| WO-2012120397-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| US-5801170-A | Heterocyclic biphenylylamides useful as 5HT1D antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-09-01 | — | — | US | disclosed |
| EP-0733048-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015954-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232083-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PRDX1, PRXL2A, PRDX4 | CYP2A6 1570/4885FAAH 605/4885MGLL 1383/4885 |
| US-20140057919-A1 | FLUORO-PYRIDINONE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PRDX1, PRXL2A, PRDX4 | CYP2A6 1570/4885FAAH 605/4885MGLL 1383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.