SCHEMBL740211

SCHEMBL740211

OB(O)Oc1ccc(F)c(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 2/20 0.44
MAPT P10636 4/20 0.41
NPC1 O15118 2/20 0.41
HTT P42858 2/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPK1 P28482 1/20 0.40
HSD17B10 Q99714 1/20 0.40
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ALDH1A1 P00352 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HTR2A P28223 2/20 0.39
SLC6A4 P31645 2/20 0.39
KCNH2 Q12809 2/20 0.39
EGFR P00533 1/20 0.39
SLC2A1 P11166 1/20 0.36
IDO1 P14902 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.35
TAS1R1 Q7RTX1 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30506427 1.00 SOS1 (0.44) SOS1MAPTNPC1HTTRAB9A
SCHEMBL30844891 0.84 PPARG (0.42) MAPTKMT2AALDH1A1HTR2ASLC6A4
SCHEMBL3367275 0.84 PPARG (0.42) MAPTKMT2AALDH1A1HTR2ASLC6A4
SCHEMBL2087980 0.81 HSP90AA1 (0.48) SMN1; SMN2HSD17B10MEN1KMT2AALDH1A1
SCHEMBL31366917 0.81 MAOB (0.40) SOS1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL3158582 0.81 MAOB (0.40) SOS1MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL28006279 0.79 HSP90AA1 (0.47) SMN1; SMN2HSD17B10MEN1KMT2AALDH1A1
SCHEMBL31019249 0.78 CA3 (0.46)
SCHEMBL29184353 0.78 VCP (0.33) SOS1NPSR1IDO1
SCHEMBL30536637 0.78 HSD17B10 (0.46) SMN1; SMN2MAPK1HSD17B10ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497392-B2 EP300/CBP inhibitor HINOVA PHARMACEUTICALS INC. (CN) 2025-12-16 US disclosed
CN-109422674-B Organic molecules, in particular for optoelectronic devices 三星显示有限公司 2024-03-22 CN disclosed
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 US disclosed
US-20230027088-A1 EP300/CBP INHIBITOR HINOVA PHARMACEUTICALS INC. (CN) 2023-01-26 US disclosed
EP-4043458-A1 EP300/CBP INHIBITOR Hinova Pharmaceuticals Inc. (CN) 2022-08-17 EP disclosed
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-12-29 US disclosed
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2020-05-21 US disclosed
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-03-24 US disclosed
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-11-08 US disclosed
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-03-09 US disclosed
EP-0675118-B1 Biphenylderivatives, process for their preparation and their use as medicaments EISAI CO LTD (JP) 2002-10-09 EP disclosed
US-20020111273-A1 Dihydrobenzene pesticides SZCZEPANSKI HENRY (CH) 2002-08-15 US disclosed
EP-0907634-B1 PESTICIDES BAYER AG (DE) 2002-01-30 EP disclosed
US-6316389-B1 PEST CONTROL, IN PARTICULAR AS FUNGICIDES, ACARICIDES AND INSECTICIDES IN CROP PROTECTION. BAYER AKTIENGESELLSCHAFT (DE) 2001-11-13 US disclosed
EP-1137641-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2001-10-04 EP disclosed
US-6281214-B1 USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS EISAI CO., LTD (JP) 2001-08-28 US disclosed
WO-2000034249-A1 PROCESS FOR PREPARING PYRIDAZIN-3-ON DERIVATIVES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-06-15 WO disclosed
EP-0907634-A1 PESTICIDES Novartis AG (CH) 1999-04-14 EP disclosed
WO-1997049672-A1 PESTICIDES NOVARTIS AG (CH) 1997-12-31 WO disclosed
EP-0675118-A2 Biphenylderivatives, process for their preparation and their use as medicaments Eisai Co., Ltd. (JP) 1995-10-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12497392-B2 EP300/CBP inhibitor EP300, MLLT1, CREBBP SOS1 2683/4885MAPT 1824/4885NPC1 1926/4885
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT SOS1 4470/4885MAPT 1692/4885NPC1 3008/4885
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide CHRM3, C3AR1, C9 SOS1 3731/4885MAPT 4809/4885NPC1 2655/4885
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CHRM3, C3AR1, C9 SOS1 3731/4885MAPT 4809/4885NPC1 2655/4885
US-20230027088-A1 EP300/CBP INHIBITOR EP300, MLLT1, CREBBP SOS1 2683/4885MAPT 1824/4885NPC1 1926/4885
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide C3AR1, C5, C9 SOS1 3676/4885MAPT 4834/4885NPC1 2937/4885
US-20020111273-A1 Dihydrobenzene pesticides CYP8B1, CBR1, DHCR24 SOS1 1050/4885MAPT 4667/4885NPC1 816/4885
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 SOS1 3651/4885MAPT 4849/4885NPC1 2642/4885
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 SOS1 3676/4885MAPT 4834/4885NPC1 2937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.