Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537294 | 0.84 | KDM4E (0.49) | MAPTKMT2ARPA1BCAT1GAA | |
| SCHEMBL28398226 | 0.81 | MEN1 (0.49) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL31420285 | 0.79 | XDH (0.50) | MEN1KMT2APOLBGAAHTT | |
| SCHEMBL10707004 | 0.75 | POLB (0.60) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL31420282 | 0.74 | KDM4A (0.49) | MAPTPOLBTDP1ALDH1A1HTT | |
| SCHEMBL28392426 | 0.72 | MAPT (0.40) | SMN1; SMN2MAPTMEN1KMT2ARPA1 | |
| SCHEMBL28392425 | 0.71 | MAPT (0.37) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL7402120 | 0.71 | PTGS2 (0.65) | SMN1; SMN2MAPTLMNAHTTPTGS2 | |
| SCHEMBL2318841 | 0.71 | RPA1 (0.68) | SMN1; SMN2MEN1KMT2ARPA1L3MBTL1 | |
| SCHEMBL28284102 | 0.71 | LMNA (0.41) | SMN1; SMN2MAPTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750550-A | RESPIRATORY SYSTEM DISORDERS | SANOFI (FR) | 1998-05-12 | — | — | US | disclosed |
| WO-1997010243-A1 | 2-(PYRAZOL-5-YL-OXYMETHYL)-1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (US) | 1997-03-20 | — | — | WO | disclosed |