Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 4/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27539865 | 0.83 | KMT2A (0.44) | ENPP3ENPP1ENPP2LMNAKMT2A | |
| SCHEMBL9538667 | 0.82 | ENPP3 (0.41) | ENPP3ENPP1ENPP2MAPTMEN1 | |
| SCHEMBL5717034 | 0.82 | EPHX2 (0.44) | ENPP3ENPP1ENPP2LTA4HEPHX2 | |
| SCHEMBL3803839 | 0.79 | ENPP3 (0.41) | ENPP3ENPP1ENPP2 | |
| SCHEMBL21616625 | 0.79 | LTA4H (0.49) | ENPP3ENPP1ENPP2LTA4HMAPT | |
| SCHEMBL3060996 | 0.79 | ENPP3 (0.41) | ENPP3ENPP1ENPP2 | |
| SCHEMBL8301422 | 0.79 | ELANE (0.43) | ENPP3ENPP1ENPP2KMT2A | |
| SCHEMBL7404085 | 0.79 | ELANE (0.43) | ENPP3ENPP1ENPP2KMT2A | |
| SCHEMBL28074505 | 0.77 | ENPP3 (0.40) | ENPP3ENPP1ENPP2MAPTMEN1 | |
| SCHEMBL8212865 | 0.77 | DPP4 (0.45) | GAAMMP2MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664010-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005068448-A1 | SULFONAMIDES ANTAGONISING N-TYPE CALCIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-07-28 | — | — | WO | disclosed |