Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1859933 | 1.00 | KDM4E (0.36) | KDM4EHSD11B1LMNAMAOAMAOB | |
| SCHEMBL740446 | 1.00 | KDM4E (0.36) | KDM4EHSD11B1LMNAMAOAMAOB | |
| SCHEMBL175503 | 0.77 | MAPK1 (0.35) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL16005 | 0.77 | MAPK1 (0.35) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL923461 | 0.75 | MAOA (0.48) | KDM4EHSD11B1LMNAMAOAMAOB | |
| SCHEMBL741407 | 0.74 | MAPK1 (0.37) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL741406 | 0.74 | MAPK1 (0.37) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL1860545 | 0.74 | MAPK1 (0.37) | KDM4ELMNASMN1; SMN2 | |
| SCHEMBL573514 | 0.74 | — | — | |
| SCHEMBL29214271 | 0.73 | HSD11B1 (0.41) | HSD11B1MAOAMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431370-A1 | Monoacylated 1,2-diaminocycloalkanes | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2012-03-21 | — | — | EP | disclosed |
| US-7935824-B2 | Ethylenediamine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-03 | — | — | US | disclosed |