Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403331 | 0.88 | CRHBP (0.48) | CRHBPCRHR2PTPN1NR3C1MTNR1A | |
| SCHEMBL8722000 | 0.77 | CRHBP (0.38) | CRHBPCRHR2PTPN1NR3C1SLC6A2 | |
| SCHEMBL8725168 | 0.77 | CRHBP (0.52) | CRHBPCRHR2PTPN1NR3C1MTNR1A | |
| SCHEMBL25152152 | 0.77 | MAPT (0.51) | SLC6A2SLC6A4SLC6A3L3MBTL1CYP2C19 | |
| SCHEMBL3299318 | 0.77 | MAPT (0.51) | SLC6A2SLC6A4SLC6A3L3MBTL1CYP2C19 | |
| SCHEMBL25152388 | 0.77 | MAPT (0.51) | SLC6A2SLC6A4SLC6A3L3MBTL1CYP2C19 | |
| SCHEMBL29185565 | 0.75 | HIF1A (0.47) | SLC6A3TSHRLMNACYP2C9MAPT | |
| SCHEMBL7405137 | 0.75 | NR3C1 (0.39) | CRHBPCRHR2NR3C1RXRARXRB | |
| SCHEMBL8147928 | 0.74 | CRHBP (0.56) | CRHBPCRHR2PTPN1NR3C1MTNR1A | |
| SCHEMBL12774503 | 0.74 | CRHBP (0.54) | CRHBPCRHR2PTPN1NR3C1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6169181-B1 | HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY | 2001-01-02 | — | — | US | disclosed |
| US-5852195-A | Pyranone compounds useful to treat retroviral infections | PHARMACIA & UPJOHN COMPANY (US) | 1998-12-22 | — | — | US | disclosed |
| WO-1995030670-A2 | PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-16 | — | — | WO | disclosed |