Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7409819 | 0.81 | GAA (0.49) | CRHBPCRHR2PTPN1NR3C1GRM2 | |
| SCHEMBL13250687 | 0.80 | CRHBP (0.56) | CRHBPCRHR2PTPN1MTNR1AMTNR1B | |
| SCHEMBL1500385 | 0.77 | GABBR2 (0.48) | MTNR1AMTNR1BKMT2AMEN1L3MBTL1 | |
| SCHEMBL6958547 | 0.75 | CRHBP (0.38) | CRHBPCRHR2PTPN1NR3C1NPC1 | |
| SCHEMBL6956625 | 0.75 | CRHBP (0.38) | CRHBPCRHR2PTPN1NR3C1NPC1 | |
| SCHEMBL7950843 | 0.75 | CRHBP (0.38) | CRHBPCRHR2PTPN1NR3C1NPC1 | |
| SCHEMBL8806910 | 0.75 | CRHBP (0.68) | CRHBPCRHR2PTPN1MTNR1AMTNR1B | |
| SCHEMBL7405135 | 0.74 | CRHBP (0.52) | CRHBPCRHR2PTPN1MTNR1AMTNR1B | |
| SCHEMBL12774503 | 0.74 | CRHBP (0.54) | CRHBPCRHR2PTPN1MTNR1AMTNR1B | |
| SCHEMBL5801482 | 0.72 | CCR5 (0.38) | CRHBPCRHR2TSHRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112286-A9 | DE NOVO SYNTHESIS OF CONJUGATES | NEKTAR THERAPEUTICS AL CORP (US) | 2008-12-18 | — | — | WO | disclosed |
| WO-2008112286-A2 | DE NOVO SYNTHESIS OF CONJUGATES | NEKTAR THERAPEUTICS (US) | 2008-09-18 | — | — | WO | disclosed |