Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089677 | 0.81 | GPR119 (0.49) | KMT2AMEN1POLBKDM4ECYP2D6 | |
| SCHEMBL622656 | 0.80 | IDO1 (0.50) | KMT2AMEN1 | |
| SCHEMBL4083846 | 0.80 | SMN1; SMN2 (0.41) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6784500 | 0.80 | ALDH1A1 (0.45) | ALDH1A1POLBMAPTNPSR1CYP3A4 | |
| SCHEMBL5848185 | 0.80 | TRPA1 (0.42) | ALDH1A1MAPTNPSR1CYP3A4 | |
| SCHEMBL7067349 | 0.79 | SMN1; SMN2 (0.51) | ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL9340622 | 0.79 | SMN1; SMN2 (0.51) | ALDH1A1KMT2AMEN1MAPTGLA | |
| Ammonia Solution, Strong SCHEMBL8172708 | 0.78 | IDO1 (0.48) | KMT2AMEN1 | |
| SCHEMBL22192890 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL3365060 | 0.77 | LTA4H (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753676-A | TREATMENT OF PSYCHOLOGICAL DISORDERS, NERVOUS SYSTEM DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5681839-A | BLOCK VOLTAGE GATED POTASSIUM CHANNEL | JOHN WYETH & BROTHER (GB) | 1997-10-28 | — | — | US | disclosed |
| WO-1995021824-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOL-2-ONE DERIVATIVES AS VOLTAGE GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD (GB) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021825-A1 | 6-ARYL-(METHYL- OR METHYLIDONE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD. (GB) | 1995-08-17 | — | — | WO | disclosed |