Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740574 | 1.00 | P2RX7 (0.41) | P2RX7USP30HPGDSPARP1HTR6 | |
| SCHEMBL762590 | 0.91 | P2RX7 (0.42) | P2RX7USP30HPGDSPARP1HTR6 | |
| SCHEMBL764261 | 0.90 | PDE4B (0.41) | USP30HPGDSPARP1HTR6ALOX5AP | |
| SCHEMBL740662 | 0.86 | P2RX7 (0.41) | P2RX7USP30HPGDSPARP1ALOX5AP | |
| SCHEMBL740661 | 0.86 | P2RX7 (0.41) | P2RX7USP30HPGDSPARP1ALOX5AP | |
| SCHEMBL741975 | 0.86 | KCNH2 (0.52) | HPGDS | |
| SCHEMBL741974 | 0.86 | KCNH2 (0.52) | HPGDS | |
| SCHEMBL741680 | 0.83 | TRPV3 (0.41) | USP30HPGDSTRPV3 | |
| SCHEMBL741679 | 0.83 | TRPV3 (0.41) | USP30HPGDSTRPV3 | |
| SCHEMBL762531 | 0.82 | TLR8 (0.44) | P2RX7USP30HPGDSHTR6BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |