Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | APLNR | P35414 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762531 | 0.92 | TLR8 (0.44) | PDE4BHTR6USP30APLNRHPGDS | |
| SCHEMBL740574 | 0.90 | P2RX7 (0.41) | HTR6USP30HPGDSTP53MAPT | |
| SCHEMBL740575 | 0.90 | P2RX7 (0.41) | HTR6USP30HPGDSTP53MAPT | |
| SCHEMBL741974 | 0.86 | KCNH2 (0.52) | HPGDS | |
| SCHEMBL741975 | 0.86 | KCNH2 (0.52) | HPGDS | |
| SCHEMBL740791 | 0.85 | ADORA2A (0.38) | TP53MAPTADORA2ATHRBSMN1; SMN2 | |
| SCHEMBL742014 | 0.81 | HTT (0.43) | PDE4BMAPT | |
| SCHEMBL762594 | 0.81 | TRPV3 (0.43) | HPGDSTP53MAPTALOX5APFEN1 | |
| SCHEMBL742013 | 0.81 | HTT (0.43) | PDE4BMAPT | |
| SCHEMBL740716 | 0.81 | CYP2D6 (0.41) | USP30HPGDSTP53MAPTALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |