Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7433749 | 0.91 | HTR6 (0.51) | KMT2AHTR6TP53HPGDHSD17B10 | |
| Iodide SCHEMBL7405172 | 0.81 | HPGD (0.41) | KMT2ATP53HPGDHSD17B10SLC2A1 | |
| SCHEMBL23817282 | 0.79 | TP53 (0.40) | KMT2ATP53HPGDHSD17B10SLC2A1 | |
| SCHEMBL23817260 | 0.78 | NR2E1 (0.41) | KMT2ATP53HPGDHSD17B10SLC2A1 | |
| SCHEMBL9597484 | 0.77 | HTR3A (0.39) | TP53HPGDHSD17B10SLC2A1NR2E1 | |
| SCHEMBL12187142 | 0.76 | HTR2B (0.37) | KMT2AHTR6TP53HPGDHSD17B10 | |
| SCHEMBL9872031 | 0.75 | METAP1 (0.39) | KMT2AHTR6HPGDMETAP1KDM4E | |
| SCHEMBL9603271 | 0.75 | HTR3A (0.38) | TP53HPGDHSD17B10SLC2A1 | |
| SCHEMBL7433024 | 0.74 | METAP1 (0.40) | HTR6METAP1HSP90AA1MITFCCR6 | |
| SCHEMBL3994101 | 0.73 | CYP3A4 (0.62) | TP53HPGDHSD17B10SLC2A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0191562-B1 | TETRAHYDROCARBAZOLONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1991-07-10 | — | — | EP | disclosed |
| US-4695578-A | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances | GLAXO GROUP LIMITED (GB) | 1987-09-22 | — | — | US | disclosed |
| EP-0191562-A2 | Tetrahydrocarbazolone derivatives | GLAXO GROUP LIMITED (GB) | 1986-08-20 | — | — | EP | disclosed |