Sugi Predict

Sugi Predict / Compounds / SCHEMBL7409052

SCHEMBL7409052

SCHEMBL7409052

NC1CCc2[nH]c3c(F)cc(F)cc3c2C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR2E1 Q9Y466 1/20 0.49
▸ HTR1B P28222 4/20 0.45
▸ HTR1D P28221 3/20 0.45
▸ HTR6 P50406 1/20 0.41
▸ CFTR P13569 1/20 0.37
▸ EGFR P00533 1/20 0.37
▸ IGF1R P08069 1/20 0.37
▸ FLT4 P35916 1/20 0.37
▸ KDR P35968 1/20 0.37
▸ DRD2 P14416 1/20 0.36
▸ DRD3 P35462 1/20 0.36
▸ APOL1 O14791 2/20 0.33
▸ GSK3A P49840 1/20 0.32
▸ GSK3B P49841 1/20 0.32
▸ VPS4B O75351 1/20 0.31
▸ VCP P55072 1/20 0.31
▸ SSTR3 P32745 1/20 0.31
▸ KCNH2 Q12809 1/20 0.31
▸ GPR84 Q9NQS5 1/20 0.31
▸ HTR1A P08908 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7406742 0.99 NR2E1 (0.48) NR2E1HTR1BHTR1DHTR6CFTR
SCHEMBL20542229 0.79 NR2E1 (0.60) NR2E1HTR1BHTR1DHTR6CFTR
SCHEMBL7408320 0.79 HTR1A (0.46) HTR1BHTR1DCFTRDRD2APOL1
Flucindole SCHEMBL121717 0.79 HTR1F (0.47) HTR1BHTR1DHTR6CFTRHTR1A
SCHEMBL833780 0.77 HTR1B (0.65) NR2E1HTR1BHTR1DHTR6EGFR
SCHEMBL833781 0.77 HTR1B (0.65) NR2E1HTR1BHTR1DHTR6EGFR
SCHEMBL833788 0.77 HTR1B (0.65) NR2E1HTR1BHTR1DHTR6EGFR
SCHEMBL7413287 0.76 APOL1 (0.37) HTR1BHTR1DCFTRDRD2DRD3
SCHEMBL7408992 0.76 HTR1D (0.40) HTR1DCFTRHTR1A
Hydrochloric Acid SCHEMBL7410180 0.75 CFTR (0.39) HTR1DCFTRHTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4710923-A2 INDOLE AHR INHIBITORS AND USES THEREOF Ikena Oncology, Inc. (US) 2026-03-18 — — EP disclosed
EP-3612030-B1 INDOLE AHR INHIBITORS AND USES THEREOF IKENA ONCOLOGY INC (US) 2025-12-24 — — EP disclosed
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2025-04-17 — — US disclosed
US-12077542-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2024-09-03 — — US disclosed
CN-110831600-B Indole AHR inhibitors and uses thereof 医肯纳肿瘤学公司 2023-10-17 — — CN disclosed
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2023-01-26 — — US disclosed
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2023-01-26 — — US disclosed
US-11358969-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-06-14 — — US disclosed
US-11358969-B2 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2022-06-14 — — US disclosed
US-20200331917-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2020-10-22 — — US disclosed
US-10689388-B1 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2020-06-23 — — US disclosed
US-10689388-B1 Indole AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2020-06-23 — — US disclosed
US-10570138-B2 Indole AHR inhibitors and uses thereof KYN THERAPEUTICS (US) 2020-02-25 — — US disclosed
US-10570138-B2 Indole AHR inhibitors and uses thereof KYN THERAPEUTICS (US) 2020-02-25 — — US disclosed
CN-110831600-A Indole AHR inhibitors and uses thereof 金恩医疗公司 2020-02-21 — — CN disclosed
US-20180327411-A1 INDOLE AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2018-11-15 — — US disclosed
US-4257952-A PSYCHOTROPIC DRUGS, ANALGESICS, ANTIHISTAMINES STERLING DRUG INC. (US) 1981-03-24 — — US disclosed
US-4172834-A ANALGESICS, ANTIHISTAMINES AND PSYCHOTROPIC AGENTS STERLING DRUG INC. (US) 1979-10-30 — — US disclosed
US-4062864-A ANALGESIC, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1977-12-13 — — US disclosed
US-3959309-A ANALGESICS, PSYCHOTROPIC, ANTIHISTAMINE STERLING DRUG INC. (US) 1976-05-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180327411-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-10570138-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-11358969-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-20200331917-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-10689388-B1 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-20250122205-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-20230028336-A1 INDOLE AHR INHIBITORS AND USES THEREOF AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885
US-12077542-B2 Indole AHR inhibitors and uses thereof AHR, ARNT, IDO1 NR2E1 391/4885HTR1B 76/4885HTR1D 179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.