Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.68 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.68 |
| ▸ | GFER | P55789 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | DRD1 | P21728 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7274082 | 0.85 | ADRB2 (0.76) | ERCC1ERCC4GFERKMT2APOLB | |
| SCHEMBL11276210 | 0.85 | L3MBTL1 (0.53) | ERCC1ERCC4GFERKMT2APOLB | |
| SCHEMBL6228641 | 0.85 | L3MBTL1 (0.53) | ERCC1ERCC4GFERKMT2APOLB | |
| Hydrochloric Acid SCHEMBL11275933 | 0.83 | L3MBTL1 (0.56) | ERCC1ERCC4GFERKMT2APOLB | |
| Hydrochloric Acid SCHEMBL5310916 | 0.83 | L3MBTL1 (0.56) | ERCC1ERCC4GFERKMT2APOLB | |
| SCHEMBL10055000 | 0.80 | L3MBTL1 (0.86) | ADRB2SLC6A2ADRA1AKCNH2HRH3 | |
| SCHEMBL10908415 | 0.80 | ADRB2 (0.87) | ERCC1ERCC4GFERKMT2APOLB | |
| SCHEMBL5305854 | 0.79 | L3MBTL1 (0.70) | OPRK1KCNH2L3MBTL1MAPTHIF1A | |
| SCHEMBL20801186 | 0.79 | L3MBTL1 (0.63) | ERCC1ERCC4CHRM1DRD1DRD3 | |
| SCHEMBL14232778 | 0.78 | RAB9A (0.69) | ERCC1ERCC4KMT2AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0845988-A4 | NOVEL FUSED ISOQUINOLINES AS DOPAMINE RECEPTOR LIGANDS | PURDUE RESEARCH FOUNDATION (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0845988-A1 | NOVEL FUSED ISOQUINOLINES AS DOPAMINE RECEPTOR LIGANDS | PURDUE RESEARCH FOUNDATION (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1997006799-A1 | NOVEL FUSED ISOQUINOLINES AS DOPAMINE RECEPTOR LIGANDS | PURDUE RESEARCH FOUNDATION (US) | 1997-02-27 | — | — | WO | disclosed |