Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 8/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416719 | 0.82 | RORC (0.42) | RORC | |
| SCHEMBL8801682 | 0.80 | SLC5A2 (0.44) | GALR3NR2F2KMT2ACXCR3POLB | |
| SCHEMBL8801731 | 0.78 | TSHR (0.40) | GALR3NR2F2TSHRCXCR3ALOX5AP | |
| SCHEMBL7415589 | 0.78 | TP53 (0.44) | GALR3NR2F2MEN1LMNATSHR | |
| SCHEMBL21323507 | 0.76 | POLB (0.40) | RORCTSHRPOLBMAPT | |
| SCHEMBL28171021 | 0.76 | TSHR (0.39) | MEN1LMNATSHRRAB9AKMT2A | |
| SCHEMBL7410652 | 0.75 | MAPT (0.42) | GALR3NR2F2NPSR1CXCR3TP53 | |
| SCHEMBL24462115 | 0.74 | OPRM1 (0.45) | LMNATSHRMAPT | |
| SCHEMBL28281353 | 0.74 | KMT2A (0.45) | MEN1LMNATSHRRAB9AKMT2A | |
| SCHEMBL7412913 | 0.73 | THRB (0.47) | RORCGALR3NR2F2CXCR3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-B1 | SUBSTITUTED INDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX INC (US) | 1997-10-22 | — | — | EP | disclosed |
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| US-5212195-A | Substituted indole antagonists derivatives which are angiotensin II | SYNTEX (U.S.A.) INC. (US) | 1993-05-18 | — | — | US | disclosed |