SCHEMBL7410652

SCHEMBL7410652

CCCn1c(Cc2ccc(Br)cc2)cc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ALPG P10696 1/20 0.42
HTT P42858 1/20 0.42
TP53 P04637 2/20 0.41
POLB P06746 2/20 0.41
CXCR3 P49682 1/20 0.40
PPARG P37231 3/20 0.40
KDM4E B2RXH2 1/20 0.40
USP2 O75604 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
NCOA2 Q15596 1/20 0.40
NCOA1 Q15788 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
GALR3 O60755 1/20 0.40
NR2F2 P24468 1/20 0.40
THRB P10828 1/20 0.39
MTNR1A P48039 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7412913 0.92 THRB (0.47) MAPTSMN1; SMN2TP53POLBCXCR3
SCHEMBL8801906 0.91 CNR2 (0.46) MAPTSMN1; SMN2HTTTP53POLB
SCHEMBL8803243 0.89 CNR2 (0.46) MAPTSMN1; SMN2HTTTP53POLB
SCHEMBL7409597 0.89 CNR2 (0.46) MAPTSMN1; SMN2HTTTP53POLB
SCHEMBL7415589 0.88 TP53 (0.44) MAPTSMN1; SMN2TP53POLBCXCR3
SCHEMBL8801731 0.85 TSHR (0.40) MAPTSMN1; SMN2TP53POLBCXCR3
SCHEMBL9172351 0.82 LPL (0.42) POLBPPARGKDM4EALDH1A1HPGD
SCHEMBL8801682 0.82 SLC5A2 (0.44) POLBCXCR3GALR3NR2F2
SCHEMBL9543780 0.81 ALDH1A1 (0.41) MAPTSMN1; SMN2TP53POLBKDM4E
SCHEMBL7462145 0.79 KMT2A (0.41) MAPTSMN1; SMN2TP53POLBCXCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640080-B1 SUBSTITUTED INDOLES AS ANGIOTENSIN II ANTAGONISTS SYNTEX INC (US) 1997-10-22 EP disclosed
EP-0640080-A1 SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. SYNTEX INC (US) 1995-03-01 EP disclosed
US-5380739-A Angiotensin II antagonists SYNTEX (U.S.A.) INC. (US) 1995-01-10 US disclosed
WO-1993023391-A1 SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS SYNTEX (U.S.A.) INC. (US) 1993-11-25 WO disclosed
US-5212195-A Substituted indole antagonists derivatives which are angiotensin II SYNTEX (U.S.A.) INC. (US) 1993-05-18 US disclosed