Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 16/20 | 0.50 |
| ▸ | MMP13 | P45452 | 12/20 | 0.50 |
| ▸ | MMP1 | P03956 | 11/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7318036 | 0.83 | NAMPT (0.46) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7418266 | 0.76 | NAMPT (0.53) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7415784 | 0.76 | NAMPT (0.53) | MMP9MMP13MMP1NAMPTALDH1A1 | |
| SCHEMBL7410709 | 0.75 | MMP9 (0.52) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7453152 | 0.71 | MMP9 (0.62) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7322223 | 0.70 | NAMPT (0.48) | MMP9MMP13MMP1NAMPTMMP2 | |
| SCHEMBL7354595 | 0.70 | MMP9 (0.48) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7317439 | 0.69 | MMP13 (0.49) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7316608 | 0.69 | MMP13 (0.47) | MMP9MMP13MMP1ADAM17NAMPT | |
| SCHEMBL7310019 | 0.68 | MMP13 (0.51) | MMP9MMP13MMP1ADAM17NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962481-A | ANTIARTHRITIC AGENTS; ANTITUMOR AGENTS; WOUND HEALING AGENTS;ANTIULCER AGENTS; ORAL DISEASES; CENTRAL NERVOUS SYTEM DISORDERS; ANTIINFLAMMATORY AGENTS; CONGESTIVE HEART FAILURE;VISION DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1999-10-05 | — | — | US | disclosed |