Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2762344 | 0.86 | SIGMAR1 (0.43) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL741114 | 0.86 | L3MBTL1 (0.38) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL740949 | 0.77 | SMN1; SMN2 (0.41) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL762310 | 0.77 | KMT2A (0.40) | SMN1; SMN2KMT2AHTT | |
| SCHEMBL2762030 | 0.76 | SIGMAR1 (0.42) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL741181 | 0.73 | POLB (0.40) | L3MBTL1SMN1; SMN2SIGMAR1PLA2G10PLA2G5 | |
| SCHEMBL2761683 | 0.72 | SMN1; SMN2 (0.39) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL740806 | 0.72 | POLB (0.39) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 | |
| SCHEMBL10073915 | 0.71 | FFAR4 (0.41) | L3MBTL1SIGMAR1KMT2A | |
| SCHEMBL3976127 | 0.71 | POLB (0.38) | L3MBTL1SMN1; SMN2OPRM1SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4081535-A | ARTHROPODICIDES, NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-28 | — | — | US | claimed |
| US-20220002308-A1 | AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) | 2022-01-06 | — | — | US | disclosed |
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |
| US-20140142096-A1 | Fused Substituted Aminopyrrolidine Derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-05-22 | — | — | US | disclosed |
| US-8618094-B2 | Fused substituted aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-12-31 | — | — | US | disclosed |
| EP-1882689-B1 | TRI- OR TETRA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2013-07-10 | — | — | EP | disclosed |
| US-8476429-B2 | Tri-, tetra-substituted-3-aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8455482-B2 | Substituted pyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-06-04 | — | — | US | disclosed |
| US-8378119-B2 | Method for producing asymmetric tetrasubstituted carbon atom-containing compound | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2013-02-19 | — | — | US | disclosed |
| US-20130029977-A9 | Fused substituted aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED | 2013-01-31 | — | — | US | disclosed |
| US-4414345-A | POLYMERS | CIBA-GEIGY CORPORATION (US) | 1983-11-08 | — | — | US | disclosed |
| US-4409346-A | POLYPROPYLENE, PHOTOSTABILITY | CIBA-GEIGY CORPORATION (US) | 1983-10-11 | — | — | US | disclosed |
| US-4393070-A | HYPOTENSIVE, VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-07-12 | — | — | US | disclosed |
| US-4386204-A | STABILIZER FOR PLASTICS AND ELASTOMERS | CIBA-GEIGY CORPORATION (US) | 1983-05-31 | — | — | US | disclosed |
| US-4380515-A | STABILIZERS FOR PLASTICS AND ELASTOMERS; HEAT AND OXIDATION RESIST | CIBA-GEIGY CORPORATION (US) | 1983-04-19 | — | — | US | disclosed |
| US-4322527-A | 6-Amino-dibenz[d,g][1,3,2]dioxaphosphocines | CIBA-GEIGY CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4307103-A | TREATMENT OF HYPERTENSION AND CARDIOVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-22 | — | — | US | disclosed |
| US-4301061-A | STABILIZERS | CIBA-GEIGY CORPORATION (US) | 1981-11-17 | — | — | US | disclosed |
| US-4259492-A | STABILIZERS FOR PLASTICS AND ELASTOMERS | CIBA-GEIGY CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |
| US-4081535-A | ARTHROPODICIDES, NEMATOCIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142096-A1 | Fused Substituted Aminopyrrolidine Derivative | NQO2, QDPR, IL4I1 | L3MBTL1 1846/4885SMN1; SMN2 3878/4885OPRM1 804/4885 |
| US-20130029977-A9 | Fused substituted aminopyrrolidine derivative | NQO2, QDPR, IL4I1 | L3MBTL1 1846/4885SMN1; SMN2 3878/4885OPRM1 804/4885 |
| US-20220002308-A1 | AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | MERTK, AXL, TYRO3 | L3MBTL1 3388/4885SMN1; SMN2 4311/4885OPRM1 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.