Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.47 |
| ▸ | CTSS | P25774 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569270 | 0.85 | CTSS (0.57) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL29604304 | 0.85 | CTSK (0.52) | CTSLCTSKLPAR1LPAR3CTRB1 | |
| SCHEMBL6254290 | 0.83 | CASP1 (0.57) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL4452037 | 0.83 | CASP1 (0.57) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL15569577 | 0.80 | CTSS (0.51) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL15569565 | 0.79 | CTSS (0.55) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL7761583 | 0.79 | CTSS (0.55) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL5550159 | 0.79 | CTSS (0.55) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL2026643 | 0.79 | SIRT2 (0.52) | CTSLCTSSCTSKALDH1A1CYP3A4 | |
| SCHEMBL7423094 | 0.79 | SIRT2 (0.53) | CTSLCTSSCTSKALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937042-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998017643-A1 | HETEROARYL SUCCINAMIDES AND THEIR USE AS METALLOPROTEINASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1998-04-30 | — | — | WO | disclosed |