Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130152 | 0.88 | HTT (0.72) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10785852 | 0.87 | AGER (0.45) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7368723 | 0.87 | KDM4E (0.49) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7407421 | 0.87 | HTT (0.51) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL10353962 | 0.85 | AGER (0.44) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7409790 | 0.84 | GAA (0.54) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7367528 | 0.83 | TDP1 (0.59) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7417048 | 0.82 | SMN1; SMN2 (0.44) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20099475 | 0.81 | HTT (0.52) | HTTHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28758846 | 0.81 | HTT (0.52) | HTTHPGDALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4935511-A | Nervous system, gastrointestinal disorders | RORER PHARMACEUTICAL CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |