Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | TLR2 | O60603 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739356 | 0.84 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL739438 | 0.73 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL14926951 | 0.66 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDGAAHIF1A | |
| SCHEMBL740648 | 0.64 | SLC22A12 (0.41) | KDM4ESMN1; SMN2KMT2AMEN1THRB | |
| SCHEMBL3477086 | 0.64 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDGAAUSP2 | |
| SCHEMBL741438 | 0.64 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL136835 | 0.63 | KDM4E (0.45) | ALDH1A1KDM4EHPGDGAAHSD17B10 | |
| SCHEMBL740706 | 0.61 | — | — | |
| SCHEMBL741116 | 0.61 | — | — | |
| SCHEMBL14924323 | 0.57 | ALDH1A1 (0.35) | ALDH1A1KDM4EHPGDHIF1AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430029-A1 | THIENO [2, 3-B]PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | Katholieke Universiteit Leuven (BE) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130842-A1 | THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2010-11-18 | — | — | WO | disclosed |