Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 8/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773812 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSLKCNA5CTSKSLC1A3 | |
| SCHEMBL17573167 | 0.81 | SIRT2 (0.48) | SMN1; SMN2CTSLCTSS | |
| SCHEMBL7411358 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSLKCNA5CTSKATM | |
| SCHEMBL8535085 | 0.79 | TSHR (0.40) | SMN1; SMN2KCNA5 | |
| SCHEMBL8333205 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSLCTSKSLC1A3SLC1A1 | |
| SCHEMBL7334593 | 0.75 | BACE1 (0.44) | SMN1; SMN2CTSLKCNA5CTSKCTSS | |
| SCHEMBL8779454 | 0.74 | LMNA (0.54) | SMN1; SMN2CTSLSLC1A3SLC1A1 | |
| SCHEMBL8779460 | 0.74 | LMNA (0.54) | SMN1; SMN2CTSLSLC1A3SLC1A1 | |
| SCHEMBL8328529 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSLCTSKSLC1A3SLC1A1 | |
| SCHEMBL18857044 | 0.72 | SMN1; SMN2 (0.62) | SMN1; SMN2CTSLATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776971-A | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5756533-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |
| US-5753660-A | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors | G. D. SEARLE & CO. (US) | 1998-05-19 | — | — | US | disclosed |
| EP-0815124-A1 | HETEROCYCLECARBONYL AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5705500-A | HIV TREATMENT | G.D. SEARLE & CO. (US) | 1998-01-06 | — | — | US | disclosed |
| EP-0813519-A1 | SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0813543-A1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996028464-A1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-09-19 | — | — | WO | disclosed |
| WO-1996028465-A1 | HETEROCYCLECARBONYL AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-09-19 | — | — | WO | disclosed |