Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411356 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSKCTSLCTSSATM | |
| SCHEMBL8773812 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSKCTSLCTSSATM | |
| SCHEMBL17573167 | 0.74 | SIRT2 (0.48) | SMN1; SMN2CTSLCTSS | |
| SCHEMBL7411458 | 0.74 | CTSL (0.46) | SMN1; SMN2CTSKCTSLCTSSCYP3A4 | |
| SCHEMBL7427049 | 0.72 | SYK (0.48) | SMN1; SMN2CTSLCTSSCYP3A4TSHR | |
| SCHEMBL13399256 | 0.71 | CYP3A4 (0.49) | SMN1; SMN2CTSKCTSLCTSSCYP3A4 | |
| SCHEMBL8668181 | 0.70 | SMN1; SMN2 (0.48) | SMN1; SMN2CTSLCTSSLMNANPC1 | |
| SCHEMBL27667885 | 0.70 | ABCB1 (0.45) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL27473268 | 0.70 | SMN1; SMN2 (0.47) | SMN1; SMN2CTSKCTSLCTSSATM | |
| SCHEMBL14127201 | 0.70 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756533-A | ENZYME INHIBITORS FOR TREATMENT OF AIDS | G.D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |