Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 7/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411356 | 0.92 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSLKCNA5CTSKSLC1A3 | |
| SCHEMBL7411358 | 0.78 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSLKCNA5CTSKATM | |
| SCHEMBL17573167 | 0.78 | SIRT2 (0.48) | SMN1; SMN2CTSLCTSS | |
| SCHEMBL8333205 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2CTSLCTSKSLC1A3SLC1A1 | |
| SCHEMBL7334593 | 0.74 | BACE1 (0.44) | SMN1; SMN2CTSLKCNA5CTSKCTSS | |
| SCHEMBL7410136 | 0.74 | ALDH1A1 (0.51) | SMN1; SMN2KCNA5 | |
| SCHEMBL8779460 | 0.73 | LMNA (0.54) | SMN1; SMN2CTSLSLC1A3SLC1A1 | |
| SCHEMBL8779454 | 0.73 | LMNA (0.54) | SMN1; SMN2CTSLSLC1A3SLC1A1 | |
| SCHEMBL8328529 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2CTSLCTSKSLC1A3SLC1A1 | |
| SCHEMBL18857044 | 0.72 | SMN1; SMN2 (0.62) | SMN1; SMN2CTSLATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804428-A1 | BIS-SULFONAMIDE HYDROXYETHYLAMINO RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0715618-A1 | HYDROXYETHYLAMINO SULPHONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0656887-A1 | HYDROXYETHYLAMINO SULFONAMIDES USEFUL AS RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1995-06-14 | — | — | EP | disclosed |