Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.60 |
| ▸ | MMP2 | P08253 | 14/20 | 0.60 |
| ▸ | MMP1 | P03956 | 11/20 | 0.60 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP10 | P09238 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7412264 | 0.90 | MMP13 (0.60) | MMP13MMP2MMP1MMP9MMP7 | |
| SCHEMBL7416696 | 0.88 | MMP13 (0.67) | MMP13MMP2MMP1MMP9ADAM17 | |
| SCHEMBL6087288 | 0.78 | MMP2 (0.67) | MMP13MMP2MMP1MMP9 | |
| SCHEMBL7299694 | 0.77 | MMP13 (0.62) | MMP13MMP2MMP1MMP9ADAM17 | |
| SCHEMBL6813468 | 0.75 | MMP1 (0.44) | MMP13MMP2MMP1MMP9ADAM17 | |
| SCHEMBL7412217 | 0.73 | KMT2A (0.64) | MMP13MMP2MMP1MMP9ADAM17 | |
| SCHEMBL7870795 | 0.69 | ALDH1A1 (0.71) | MMP1ALDH1A1GAA | |
| SCHEMBL16839804 | 0.68 | MAPT (0.51) | — | |
| SCHEMBL6955637 | 0.67 | MMP1 (0.76) | MMP13MMP2MMP1MMP9ADAM17 | |
| SCHEMBL1464359 | 0.67 | KMT2A (0.73) | ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6417229-B1 | ENZYME INHIBITORS | PFIZER INC | 2002-07-09 | — | — | US | claimed |
| EP-1088550-A1 | alpha-sulfonylamino hydroxamic acid inhibitors of matrix metallo-proteinases for the treatment of peripheral or central nervous system disorders | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |