Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ME3 | Q16798 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 1/20 | 0.44 |
| ▸ | ME1 | P48163 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15801111 | 0.81 | NPC1 (0.54) | RAB9AALDH1A1NPC1LMNASLC18A3 | |
| SCHEMBL22537879 | 0.81 | DRD2 (0.53) | RAB9ANPC1SLC18A3MMP2MMP9 | |
| SCHEMBL8340141 | 0.78 | FFAR4 (0.63) | FFAR4SIGMAR1MEN1KMT2A | |
| SCHEMBL6674717 | 0.78 | MEN1 (0.49) | SLC18A3MMP2MMP9MMP13SIGMAR1 | |
| SCHEMBL5254053 | 0.78 | USP2 (0.64) | RAB9AALDH1A1NPC1POLBLMNA | |
| SCHEMBL7679166 | 0.77 | MMP2 (0.49) | ALDH1A1SLC18A3MMP2MMP9MMP13 | |
| SCHEMBL11190153 | 0.77 | MAPT (0.54) | RAB9AALDH1A1NPC1POLBLMNA | |
| SCHEMBL4573389 | 0.77 | POLB (0.46) | RAB9AALDH1A1NPC1POLBLMNA | |
| SCHEMBL7446491 | 0.77 | MBTD1 (0.55) | LMNASLC18A3SIGMAR1DRD2 | |
| SCHEMBL8363020 | 0.76 | LMNA (0.49) | LMNASLC18A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0102227-B1 | 2(1H)-PYRIDINONES, USEFUL AS CARDIOTONIC AGENTS, AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1989-05-03 | — | — | EP | disclosed |
| US-4607037-A | Cardiotonic 2(1H)-pyridinones | WARNER-LAMBERT COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4503061-A | Substituted phenyl-pyridinones as cardiotonic agents | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0102227-A2 | 2(1H)-pyridinones, useful as cardiotonic agents, and their production | WARNER-LAMBERT COMPANY (US) | 1984-03-07 | — | — | EP | disclosed |