Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | SELL | P14151 | 1/20 | 0.40 |
| ▸ | SELP | P16109 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27615088 | 0.86 | ALDH1A1 (0.41) | MMP2IMPDH2ALDH1A1CDC25BCASP6 | |
| SCHEMBL788899 | 0.86 | SELL (0.45) | MMP2SELLSELPHMGB1ALDH1A1 | |
| SCHEMBL2925754 | 0.83 | SELL (0.52) | SELLSELPALDH1A1KDM4EKMT2A | |
| SCHEMBL299374 | 0.81 | SELL (0.41) | SELLSELPHMGB1KDM4ETSHR | |
| SCHEMBL7076994 | 0.81 | ALDH1A1 (0.40) | MMP2IMPDH2ALDH1A1CDC25BCASP6 | |
| SCHEMBL10741043 | 0.80 | ERN1 (0.42) | MMP2SELLSELPALDH1A1KDM4E | |
| SCHEMBL7676286 | 0.80 | KDM4E (0.44) | SELLSELPHMGB1ALDH1A1KDM4E | |
| SCHEMBL15962085 | 0.79 | MMP2 (0.50) | MMP2SELLSELPHMGB1ALDH1A1 | |
| SCHEMBL461024 | 0.78 | MMP2 (0.50) | MMP2HMGB1IMPDH2ALDH1A1CDC25B | |
| SCHEMBL996835 | 0.78 | CYP1A2 (0.44) | SELLSELPALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990006113-A1 | SUBSTITUTED SATURATED AND UNSATURATED INDOLE QUINOLINE AND BENZAZEPINE CARBOXAMIDES AND THEIR USE AS PHARMACOLOGICAL AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| US-4920219-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |