Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11231296 | 0.78 | CSNK1A1 (0.44) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL4879110 | 0.76 | ALDH1A1 (0.42) | KMT2AALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL24485 | 0.74 | HPGD (0.51) | KMT2AALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL10438254 | 0.73 | NPC1 (0.45) | KMT2ANPC1RAB9AMAPTHTT | |
| SCHEMBL31588107 | 0.72 | KMT2A (0.71) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL17673999 | 0.72 | KMT2A (0.71) | KMT2ANPC1RAB9AALDH1A1MAPT | |
| SCHEMBL5323575 | 0.72 | LMNA (0.45) | KMT2ARAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL8548846 | 0.72 | KMT2A (0.60) | KMT2ANPC1RAB9AALDH1A1HTT | |
| SCHEMBL11111898 | 0.70 | TSHR (0.58) | KMT2AALDH1A1MAPTHTTTDP1 | |
| SCHEMBL19975330 | 0.69 | KMT2A (0.59) | KMT2ANPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674879-A | Compositions including and methods of using conformationally restricted angiotensin II antagonist | G.D. SEARLE & CO. (US) | 1997-10-07 | — | — | US | disclosed |
| US-5426105-A | Cardiovascular disorders | G.D. SEARLE & CO. (US) | 1995-06-20 | — | — | US | disclosed |