Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762502 | 0.84 | HPGDS (0.52) | MPOGRIN2BMAPK1LMNACYP1A2 | |
| SCHEMBL2514536 | 0.83 | HTR2B (0.61) | MAPK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL742415 | 0.83 | HTR2B (0.61) | MAPK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL2520100 | 0.83 | HTR2B (0.61) | MAPK1CYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL7906028 | 0.77 | HTR2B (0.51) | MPOLMNAKMT2AMAPT | |
| SCHEMBL17102175 | 0.75 | TDO2 (0.48) | MPO | |
| SCHEMBL17513277 | 0.73 | GRIN2B (0.75) | MPOGRIN2BMAPK1LMNACYP1A2 | |
| SCHEMBL739141 | 0.73 | HTR2B (0.71) | KDM4EPOLB | |
| SCHEMBL2709675 | 0.73 | GRIN2B (0.56) | MPOGRIN2BMAPK1CYP2C19SMN1; SMN2 | |
| SCHEMBL6169490 | 0.72 | GRM5 (0.45) | MAPK1LMNACYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |