Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 5/20 | 0.50 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762565 | 0.85 | HPGDS (0.57) | HPGDSMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL19408169 | 0.85 | HPGDS (0.57) | HPGDSMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL739188 | 0.85 | HPGDS (0.57) | HPGDSMAPK1POLBKDM4ECYP1A2 | |
| SCHEMBL741433 | 0.84 | MPO (0.55) | GRIN2BMPOMAPK1LMNAPOLB | |
| SCHEMBL19385385 | 0.83 | HPGDS (0.48) | HPGDSCHEK2GRIN2BMAPK1LMNA | |
| SCHEMBL1299150 | 0.81 | SMN1; SMN2 (0.52) | HPGDSLMNAPOLBKDM4EBRD3 | |
| SCHEMBL10292467 | 0.79 | HPGDS (0.50) | HPGDSCHEK2GRIN2BMAPK1LMNA | |
| SCHEMBL20444734 | 0.78 | CHEK2 (0.44) | CHEK2BACE1BACE2KDM4ECYP2D6 | |
| SCHEMBL17097142 | 0.78 | BACE1 (0.45) | HPGDSCHEK2BACE1BACE2BRD3 | |
| SCHEMBL741851 | 0.77 | PARP1 (0.51) | HPGDSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |