Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 15/20 | 0.50 |
| ▸ | MMP13 | P45452 | 11/20 | 0.50 |
| ▸ | MMP2 | P08253 | 8/20 | 0.50 |
| ▸ | MMP8 | P22894 | 3/20 | 0.50 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 4/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675605 | 0.91 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL3950424 | 0.87 | ADAM17 (0.46) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL6676085 | 0.86 | ADAM17 (0.46) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL6331599 | 0.85 | ALDH1A1 (0.54) | MMP13MMP2ALDH1A1MMP3CA12 | |
| SCHEMBL6504827 | 0.84 | MMP13 (0.55) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL6508689 | 0.83 | MMP13 (0.53) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL3943732 | 0.82 | MMP13 (0.66) | ADAM17MMP13MMP2MMP8MMP9 | |
| Hydrochloric Acid SCHEMBL6498659 | 0.82 | MMP13 (0.65) | ADAM17MMP13MMP2MMP8MMP9 | |
| SCHEMBL6625710 | 0.82 | MMP13 (0.46) | ADAM17MMP13MMP2MMP8MMP7 | |
| SCHEMBL7414482 | 0.81 | MMP3 (0.51) | ADAM17MMP13MMP2MMP8MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1149074-B1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | WYETH CORP (US) | 2004-10-20 | — | — | EP | claimed |
| US-7488754-B2 | Method for the treatment of polycystic kidney disease | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| EP-1149074-B1 | ACETYLENIC SULFONAMIDE THIOL TACE INHIBITORS | WYETH CORP (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2002083112-A2 | METHOD FOR THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE | WYETH HOLDINGS CORPORATION (US) | 2002-10-24 | — | — | WO | disclosed |
| US-6313123-B1 | FOR THERAPY OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, SEPSIS, AIDS, ULCERATIVE COLITIS, MULTIPLE SCLEROSIS, CROHN'S DISEASE AND DEGENERATIVE CARTILAGE LOSS | AMERICAN CYANAMID COMPANY | 2001-11-06 | — | — | US | disclosed |