Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 5/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGAV | P06756 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | CASR | P41180 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 4/20 | 0.36 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410551 | 0.96 | ITGB3 (0.41) | SLC7A5ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7410381 | 0.96 | ITGB3 (0.41) | SLC7A5ITGB3ITGAVITGA2BITGB1 | |
| SCHEMBL7408424 | 0.87 | ALDH1A1 (0.41) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7375593 | 0.87 | ALDH1A1 (0.42) | ITGB3ITGA2BCASRF2ALDH1A1 | |
| SCHEMBL7409600 | 0.84 | MAPT (0.42) | PKMALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL7466483 | 0.84 | NPC1 (0.45) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7380572 | 0.84 | ITGB3 (0.40) | SLC7A5NOS3NOS1NOS2ITGB3 | |
| SCHEMBL7382269 | 0.83 | NR1H4 (0.41) | ITGB3ITGAVITGA2BF2ALDH1A1 | |
| SCHEMBL7376793 | 0.83 | RAB9A (0.38) | ITGB3ITGA2BF2ALDH1A1SMN1; SMN2 | |
| SCHEMBL7410561 | 0.82 | ITGB3 (0.40) | SLC7A5ITGB3ITGAVITGA2BITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |