Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 5/20 | 0.38 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410381 | 1.00 | ITGB3 (0.41) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| Phenylalanine SCHEMBL7414620 | 0.96 | SLC7A5 (0.47) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7408424 | 0.91 | ALDH1A1 (0.41) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7375593 | 0.91 | ALDH1A1 (0.42) | ITGB3ITGA2BF2CASRLMNA | |
| SCHEMBL7466483 | 0.88 | NPC1 (0.45) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7409600 | 0.88 | MAPT (0.42) | LMNANR1H4MAPTNPSR1MEN1 | |
| SCHEMBL7382269 | 0.86 | NR1H4 (0.41) | ITGB3ITGA2BITGAVF2LMNA | |
| SCHEMBL7376793 | 0.86 | RAB9A (0.38) | ITGB3ITGA2BF2LMNAMAPT | |
| SCHEMBL7410561 | 0.86 | ITGB3 (0.40) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7410389 | 0.86 | ITGB3 (0.40) | ITGB3ITGA2BITGB1ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |