SCHEMBL7415219

SCHEMBL7415219

O=C(OCCC1CCCCN1)n1ccc2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.43
CHRNA4 P43681 2/20 0.43
HTR3E A5X5Y0 1/20 0.43
HTR3B O95264 1/20 0.43
CHRNA7 P36544 1/20 0.43
HTR3A P46098 1/20 0.43
HTR3D Q70Z44 1/20 0.43
HTR3C Q8WXA8 1/20 0.43
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.39
PIM1 P11309 1/20 0.39
PIM2 Q9P1W9 1/20 0.39
NOTUM Q6P988 1/20 0.39
NPY1R P25929 2/20 0.38
CACNA2D1 P54289 1/20 0.38
CACNA1B Q00975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7419960 0.75 HPGD (0.41) KMT2A
SCHEMBL7169526 0.75 NOTUM (0.56) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
SCHEMBL7415215 0.73 BCHE (0.55) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
Hydrochloric Acid SCHEMBL7478009 0.73 MEN1 (0.43) HTR3ACYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7415222 0.73 SLC6A3 (0.45) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
Hydrochloric Acid SCHEMBL7423348 0.71 NPC1 (0.51) CHRNB2CHRNA4KMT2ANOTUMTSHR
SCHEMBL600415 0.70 NOTUM (0.61) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
SCHEMBL30109103 0.70 NOTUM (0.61) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
SCHEMBL5635573 0.70 NOTUM (0.53) CHRNB2CHRNA4HTR3EHTR3BCHRNA7
SCHEMBL7162470 0.70 RAB9A (0.50) CHRNB2CHRNA4HTR3EHTR3BCHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629198-A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS SMITHKLINE BEECHAM PLC (GB) 1994-12-21 EP disclosed
WO-1993018027-A1 NITROGEN CONTAINING HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS SMITHKLINE BEECHAM PLC (GB) 1993-09-16 WO disclosed