Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17138190 | 0.87 | KMT2A (0.48) | CYP3A4KMT2AGAAACHELMNA | |
| SCHEMBL27578836 | 0.81 | LMNA (0.50) | MTNR1AMTNR1BKMT2AGAAACHE | |
| SCHEMBL28389846 | 0.80 | LMNA (0.61) | ALDH1A1SMN1; SMN2CYP3A4KMT2AGAA | |
| SCHEMBL27772417 | 0.78 | FFAR1 (0.40) | KMT2AACHE | |
| SCHEMBL48418 | 0.77 | ALDH1A1 (0.70) | ALDH1A1RECQLKMT2AGAAMAPK1 | |
| SCHEMBL7415224 | 0.77 | LMNA (0.45) | ALDH1A1RECQLMTNR1AMTNR1BKDM4E | |
| SCHEMBL2448081 | 0.76 | L3MBTL1 (0.47) | ALDH1A1SMN1; SMN2KMT2AGAALMNA | |
| Ethylene Glycol SCHEMBL7206927 | 0.75 | ALDH1A1 (0.67) | ALDH1A1RECQLKMT2AGAAMAPK1 | |
| SCHEMBL28220738 | 0.75 | ACHE (0.47) | CYP3A4KMT2AACHELMNA | |
| SCHEMBL11082567 | 0.75 | L3MBTL1 (0.50) | ALDH1A1RECQLMTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173415-A1 | DIPHENYLUREA DERIVATIVES | AstraZeneca AB (SE) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000064866-A1 | DIPHENYLUREA DERIVATIVES | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |